Real-time mapping of ultrasound-activated bubbles in the body IBME, University of Oxford

Researchers at the University of Oxford develop and patent Passive Acoustic Mapping, the first method that makes it possible to detect, localize and monitor ultrasound-activated bubbles (acoustic cavitation) during ultrasound treatment at depth within the body. This paves the way for translation of cavitation-based therapies to the clinic by providing an essential tool for real-time treatment monitoring. A patent, now granted, is filed in 2008.


Tissue fractionation with pre-injected ultrasound-activated bubbles IBME, University of Oxford

Researchers within the University demonstrate for the first time that fractionation of collagen within the spinal disc is possible using modest ultrasound pressures that can be safely delivered to the spine if bubbles are pre-injected at the centre of the disc. A patent, now granted, is filed in 2011.


Stabilisation of air nanobubbles on solid injectable sono-sensitive particles IBME, University of Oxford

Researchers at the University of Oxford develop a new method for stabilizing gas nanobubbles for injection by trapping them within solid cup-shaped particles (now called Sono-Sensitive Particles). This enables the reliable delivery of billions of stable, consistently sized air nanobubbles that survive the very steep pressures encountered in the intervertebral disc to seed sustained acoustic cavitation for tissue fractionation. These SSPs are successfully patented in late 2014.


Steerable ultrasound delivery to the spinal disc IBME, University of Oxford

Researchers at the University of Oxford develop a new type of modular ultrasound array specifically designed to enable delivery of ultrasound to the spine. The lego-like modular array makes it possible to overcome the barriers to ultrasound delivery presented by bone and to move the focus of the ultrasound beam within the disc without physically moving the array. Researchers work with the CT scans from numerous patients to establish the optimum design and prototype it. A patent application is filed in late 2016.


Incorporation of OrthoSon Ltd to Develop Ultrasound-Enhanced Spinal Therapies

OrthoSon raises £940K in pre-seed funding to secure the intellectual property and enable the development of the technology.


Appointment of OrthoSon CEO Rich Simmonds

Rich Simmonds appointed as Chief Executive Officer to develop the plan, recruit the team and negotiate the key supply agreements in preparation for the technology transfer from the Oxford University.


Award of £1.2m Innovate UK grant to OrthoSon

OrthoSon successfully secures £1.2M in non-dilutive grant funding to develop the fully functional prototype and perform its validation in preclinical models by 2020.


Secures £1.8m Seed Round

OrthoSon raises £1.8m in seed funding in November 2019 led by Oxford Technology and Innovations EIS Fund (OTIF) and its advisor Oxford Investment Consultants.


Innovate UK grant to further development of ultrasound technology in back pain

Injectable Hydrogel Combo.Oxford, UK, July 29 2020 – OrthoSon, an Oxford University spin-out which is developing a novel ultrasound-based treatment for lower back and neck pain, has been awarded a £250,000 extension to its £1.2m Biomedical Catalyst award. The extension, which will enable completion of the device prototype and generation of preclinical data, has been awarded under the COVID-19 Continuity Grant scheme provided by Innovate UK, the UK’s Innovation Agency. The information and prototype generated under the Biomedical Catalyst grant will accelerate development of OrthoSon’s technology towards first-in-human trials. Its product is expected to restore spinal function as well as reduce pain in a way which is significantly safer, less invasive and more cost-effective than current surgical options, with reduced need for opioid-based pain relief. Download our press release here


In the Press - Medtech Insight

Start-Up Spotlight: OrthoSon Targets Back Pain With Ultrasound, Injectable Hydrogel Combo. Read the full article here.


OrthoSon's move to new premises

OrthoSon is pleased to announce its move to new premises at The Oxford Science Park. Read our press release here

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